Plecanatide & Linaclotide are two medications developed by two different firms, but both are closely treating Irritable Bowel Syndrome. Synergy Pharmaceuticals is developing Plecanatide while Ironwood Pharmaceuticals is developing Linaclotide. These drugs are aimed at those with predominant IBS constipation with abdominal pain associated with IBS. Both the medications, Plecanatide & Linaclotide are agonists that activate the GC-C (guanylate cyclase C) receptor in the intestinal tract mucosa covering. It triggers the release of proteins CFTR (cystic fibrosis transmembrane conductance regulator) when this receptor is stimulated. Such CFTR proteins enhance intestinal material distribution by increasing water & chloride secretions while at the same time reducing liquid absorption. These also seem to help reduce inflammation. The end result is identical to the only IBS medication currently available Lubiprostone(Amitiza), Lubiprostone operates differently, resulting in a...